CANCER DU CAVUM PDF

Nishura Very rarely does Epstein-Barr virus lead to cancer, which suggests a variety of influencing factors. Outline Masquer cander plan. Journal of Translational Medicine. Acinic cell carcinoma Mucoepidermoid carcinoma Adenoid cystic carcinoma Salivary duct carcinoma Epithelial-myoepithelial carcinoma Polymorphous low-grade adenocarcinoma Hyalinizing clear cell carcinoma. Undifferentiated cells are cells that do not have their mature features or functions.

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Signs and symptoms related to the primary tumor include trismus , pain, otitis media , nasal regurgitation due to paresis loss of or impaired movement of the soft palate , hearing loss and cranial nerve palsy paralysis. Larger growths may produce nasal obstruction or bleeding and a "nasal twang".

Metastatic spread may result in bone pain or organ dysfunction. Rarely, a paraneoplastic syndrome of osteoarthropathy diseases of joints and bones may occur with widespread disease. Causes[ edit ] NPC is caused by a combination of factors: viral, environmental influences, and heredity.

The World Health Organization does not have set preventative measures for this virus because it is so easily spread and is worldwide. Very rarely does Epstein-Barr virus lead to cancer, which suggests a variety of influencing factors. Other likely causes include genetic susceptibility, consumption of food in particular salted fish [4] containing carcinogenic volatile nitrosamines.

The cause of NPC particularly the endemic form seems to follow a multi-step process, in which EBV, ethnic background, and environmental carcinogens all seem to play an important role.

More importantly, EBV DNA levels appear to correlate with treatment response and may predict disease recurrence, suggesting that they may be an independent indicator of prognosis. The mechanism by which EBV alters nasopharyngeal cells is being elucidated [8] to provide a rational therapeutic target. The World Health Organization classifies nasopharyngeal carcinoma in three types, in order of frequency: Non-keratinizing squamous cell carcinoma; keratinizing squamous cell carcinoma; and basaloid squamous cell carcinoma.

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